SHORT CURRICULUM VITAE

 

Domenico Vittorio Delfino

 

DATE OF BIRTH:                     January 1, 1959

PLACE OF BIRTH:                   Reggio di Calabria, Italy

CITIZENSHIP:                          Italian

EDUCATION

1986    School of Medicine, University of Perugia, Perugia, Medical Degree

1986    School of Medicine, University of Perugia, Perugia, Medical Board

 

SCIENTIFIC WORK

1987-91 Italy, Family Medicine

1988-92 Univerity “La Sapienza”, Rome, Italy, “Experimental Medicine” Ph.D. Degree

1991-94 Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A., Research Associate

1994       23o meeting International Society of Experimental Hematology

               Minneapolis, MN, U.S.A., Award                   

1994-95  Italy, Emergency Medicine                              

1995       Departiment of Clinical Medicine, Patology and Pharmacology; University of Perugia, Perugia, Italy, Assistant Professor

1998       Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, U.S.A., Visiting Professor

2001       Department of Clinical and Experimental Medicine, Section of Pharmacology, Toxicology and Chemotherapy, University of Perugia Medical School, Perugia, Italy; Associate Professor

2001       Department of Immunology and Microbiology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, U.S.A., Visiting Professor

 

SCIENTIFIC MEMBER

 

Italian board of Clinical Medicine

International Society for Natural Immunity

International Society of Experimental Hematology

Italian Society of Pharmacology

Italian Society of Immunology

Italian Society of Hematology

Italian Society of Immunopharmacology

 

INTERNATIONAL PUBLICATIONS

1) G. Migliorati, L.Cannarile, F.D’Adamio, D. Delfino e C. Riccardi.  Effetto di citochine sulla generazione di cellule NK e sulla resistenza contro cellule tumorali.

Journal of Chemotherapy, supplemento al n.2, 546, 1990.  IF: 0.678

2)         G. Migliorati, D. Delfino, F. D’Adamio, C. Riccardi.  Immunopharmacology of natural reactivity: role of IFN-gamma and TNF-alpha in NK cell

generation from bone marrow precursors.   Journal of Chemotherapy, vol.III, supplement n.3, June 1991.  IF: 0.678

3)        Graziella Migliorati, Paolo Cornaglia-Ferraris, Lorenza Cannarile, Domenico Delfino, Francesca D’Adamio, Flavio Mosci, Riccardo Stradi, Elisabetta Rossi, Guido Guidi and Carlo Riccardi.  Effect of a new peptidyl-hypoxantine derivative on natural killer and antitumor activity.  Cancer Detection and Prevention, volume 15, issue 4, 391, 1991.  IF: 0.69

4)         Domenico Delfino, Francesca D’Adamio, Graziella Migliorati, Carlo Riccardi.  Growth of murine natural killer cells from bone marrow in vitro: Role of  TNFa and IFNg.  Int. J.Immunopharmac., vol.13, No.7, pp.943-954, 1991.  IF: 0.531

5)         Emira Ayroldi, Lorenza Cannarile, Francesca D’Adamio, Domenico Delfino, Graziella Migliorati, Carlo Riccardi.  Long-Term cultures of mouse bone marrow cells: A model for studying the generation of natural killer cells.  Nat Immun 1992;11:317-327.  IF: 1.028

6)         Fausto Vecchini, Domenico Delfino, Kenneth D. Patrene, Albert DeLeo, Lina Lu, Ronald B. Herberman, and Sallie S. Boggs.  Generation of natural killer (NK) cells from long-term cultures of mouse bone marrow.  Nat Immun 1993;12:1-16.  IF: 1.028

7)         Domenico V. Delfino, Kenneth D. Patrene, Albert B DeLeo, Rita DeLeo, Ronald B. Herberman, and Sallie S. Boggs.  Role of CD44 in the development of NK cells from precursors in long-term cultures of mouse bone marrow.  J.Immunol.  1994; 152:5171.  IF: 7.166

8)         Migliorati G., Nicoletti I., Delfino D., Maggioni A., Riccardi C.  Pidotimod induce morte apoptotica ed inibisce l’attività proliferativa di cellule tumorali YAC-1 in vitro.

            Drugs Exptl.Clin.Res.  XIX (Suppl.) 1-7 (1993).  IF: 0.536

9)         G.Migliorati, D.Delfino, G.Nocentini, I.Nicoletti and C.Riccardi.  Tumor Cell Death induced through the receptor for interleukin-2.  Int. J. Immunopathol. Pharmacol.  1995;  8:161.  IF: 0.339

10)       D.V.Delfino, K.D.Patrene, A.DeLeo, R.DeLeo, R.B.Herberman and S.S.Boggs.  Natural Killer Cell Precursors in the CD44neg/dim TCRneg Population of Mouse Bone Marrow.

            Blood, 87:2394, 1996.  IF: 8.372

11)       Emira Ayroldi, Graziella Migliorati, Lorenza Cannarile, Rosalba Moraca, Domenico V. Delfino, and Carlo Riccardi.  CD2 rescues T cells from T-cell receptor/CD3 apoptosis: a role for the Fas/Fas-L system.  Blood.  89:3717, 1997.  IF: 8.372

12)       L.Cannarile, G.Venditti, E.Ayroldi, D.V.Delfino, G.Migliorati.  Dexamethasone modulates IL-13 and IL-10 expression.  Int. J. Immunopathol. Pharmacol.  10:175, 1997.  IF: 0.339

13)         Domenico V. Delfino, Enrica Lepri, Emira Ayroldi, Graziella Migliorati, Sallie S. Boggs, Carlo Riccardi.  Suppression of Natural Killer Cell Differentiation by Activated T Lymphocytes in Long-term Cultures of Mouse Bone Marrow.  Exp. Hematol. 26:2, 1998.  IF: 3.467

14)       Enrica Lepri, Domenico V. Delfino, Graziella Migliorati, Rosalba Moraca, Emira Ayroldi, Carlo Riccardi.   Functional expression of Fas on mouse bone marrow stromal cells: up-regulation by TNF-α and IFN-γ.  Exp.Hematol. 26:1202, 1998.  IF: 3.467

15)       Emira Ayroldi, Ornella Zollo, Lorenza Cannarile, Francesca D’Adamio, Ursula Grohmann, Domenico V. Delfino, and Carlo Riccardi.  Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death (AICD): Interleukin-2-Independent Inhibition of FAS/FASL Expression and Cell Death.  Blood. 92:4212, 1998.  IF: 8.372

16)       Andrea Bartoli, Carlo Riccardi, Domenico V. Delfino.  Corticosteroids as Stress-Induced Cell Defense Mechanism.  Dev Brain Dysfunct. Vol. 10; pp. 475-481, 1998.  IF: 0.372

17)       Emira Ayroldi, Francesca D’Adamio, Ornella Zollo, Massimiliano Agostini, Rosalba Moraca, Lorenza Cannarile, Graziella Migliorati, Domenico V. Delfino, and Carlo Riccardi. Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand gene.  Blood.  94:1, 1999.  IF: 8.372

17)       Domenico V. Delfino, Barbara Di Marco, Cristina Marchetti, Andrea Bartoli, Emira Ayroldi, Stefano Bruscoli, Massimiliano Agostini, Stefania Spinicelli, Ornella Zollo, Graziella Migliorati.  Effect of interleukin-2 on generation of natural killer cells: role of major histocompatibility complex class I in B6 and TAP-1^-/- mice.  J Chemother. 12:160-6, 2000.  IF: 0.678

18)       C. Riccardi, O. Zollo, G. Nocentini, S. Bruscoli, F. D’Adamio, L. Cannarile, D. Delfino, E. Ayroldi, G. Migliorati.  Glucocorticoid hormones in the regulation of cell death.  Thèrapie.  55:165-169, 2000.  IF: 0.476            

19)       Giuseppe Nocentini, Andrea Bartoli, Simona Ronchetti, Linda Giunchi, Amelia Cupelli, Domenico Delfino, Graziella Migliorati, and Carlo Riccardi.  Gene structure and chromosomal asssignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family.  DNA and cell biology.  19:205-217, 2000.  IF: 2.158 

20)       G. Nocentini, S. Ronchetti, A. Bartoli, S. Spinicelli, D. Delfino, L. Brunetti, G. Migliorati, and C. Riccardi.  Identification of three novel mRNA splice variants of GITR.  Cell death and Differ.  7:408-410, 2000.  IF: 4.021

21)      Domenico V. Delfino, Margarita Salcedo, Barbara Di Marco, Emira Ayroldi, Giuseppe Nocentini, Stefano Bruscoli, Luigi Brunetti, Hans-Gustaf Ljunggren and Carlo Riccardi.  Differentiation of Ly49s-positive or -negative natural killer cells is inhibited by anti-H-2^b monoclonal antibodies acting at the level of bone marrow progenitors from B6 mice.  Cell Growth & Differentiation.  12:51-60, 2001.  IF: 4.2

22)     Massimiliano Agostini, Barbara Di Marco, Stefania Spinicelli, Stefano Bruscoli, Domenico V. Delfino.  IL-2-driven natural killer cell generation: role of anti-H-2^b monoclonal antibodies and stromal cells in controlling quantitative and repertoire changes.  J Chemotherapy.  13:527-534, 2001.  IF: 0.678    

23)     Massimiliano Agostini, Barbara Di Marco, Giuseppe Nocentini, Domenico V. Delfino.  Oxidative stress and apoptosis in immune response.  Int J Immunopathol Pharmacol.  15:157-164, 2002.  IF: 3.927           

24)     Marchetti Maria Cristina, Barbara Di Marco, Maria Cristina Santini, Andrea Bartoli, Domenico V. Delfino, Carlo Riccardi.  Dexamethasone-induced thymocytes apoptosis requires glucocorticoid receptor nuclear translocation but not mitochondrial membrane potential transition.  Toxicol Lett.  139:175-180, 2003.  IF: 2.224

25)    Andrea Bartoli, Katia Fettucciari, Ilaria Fetriconi, Emanuela Rosati, Mauro Di Ianni, Antonio Tabilio, Domenico V. Delfino, Ruggero Rossi, Pierfrancesco Marconi.  Effect of trichostatin a and 5′-azacytidine on transgene reactivation in U937 transduced cells.  Pharmacol Res.  48:111-118, 2003.  IF: 1.144

26)    Domenico V. Delfino, Massimiliano Agostini, Stefania Spinicelli, Carlo Riccardi.  Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice.  BLOOD. 104:4134-4141, 2004.  IF: 10.120

27)   Domenico V. Delfino, Massimiliano Agostani, Stefania Spinicelli, Carmine Vacca, Carlo Riccardi.  Inhibited cell death, NF-kB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ.  Int Immunopharmacol.  6/7:1126-1134, 2006.  IF: 1,827

28)   Domenico V. Delfino, Nicola Pozzesi, Stefania Gizzi, Massimiliano Agostini, Carmine Vacca, Lorenza Cannarile, Carlo Riccardi.  IL-2 induces an altered CD4/CD8 ratio of splenic T lymphocytes from transgenic mice overexpressing the glucocorticoid-induced protein GILZ.  J Chemother, 5:562-569, 2007.  IF: 1,147